Enzymes for DNA removal

Unique and most efficient product: Benzonase^® endonuclease

Removal of DNA and RNA brings an overall improvement in further downstream processing-steps. The best method for this is enzymatic cleavage by means of Benzonase^®, a non-specific, recombinant endonuclease produced from E.coli and which separates DNA and RNA into fragments comprising <10 soluble base pairs, in keeping with regulatory criteria stipulating that fragments need to be <100 bp.

You want to eliminate nucleic acids from recombinant proteins?

Benzonase^® endonuclease is the only effective biochemical method of removing DNA and RNA in the laboratory and in industrial-scale processes. This product is a unique, genetically engineered endonuclease, not of animal origin, offering a variety of advantages over existing methods of removal.

High purity

Our product ensures that you will meet the highest possible purity standards for biopharmaceuticals. Benzonase^® endonuclease is manufactured and exclusively distributed by Merck Darmstadt, Germany, and its subsidiaries. The production techniques used to manufacture Benzonase^® endonuclease ensure a product of exceptionally high quality and purity.

Ideal for a variety of applications

Benzonase^® endonuclease is free of detectable proteolytic activity and possesses an exceptionally high specific activity. It is effective over a wide range of operating conditions and is ideal for a variety of applications including purification of proteins and other biologicals, reduction of viscosity caused by nucleic acids, and sample preparation in electrophoresis and chromatography.

Reduce process time

It has proven its value in the laboratory and is successfully applied in various processes throughout the pharmaceutical and biotechnological industry.

Maximize productivity

You can maximize your productivity thanks to the higher purity, higher recovery and easier scale-up.

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